hrp0097rfc9.3 | Diabetes and insulin 2 | ESPE2023

Impaired Insulin Secretion as a Pathophysiology Underlying Abnormal Glucose Metabolism in Pediatric Acute Lymphoblastic Leukemia (ALL) Survivors: A Study Comparing Glucose Metabolism between ALL Survivors and Simple Obese Children

Supho Warittha , Mahachoklertwattana Pat , Anurathapan Usanarat , Pongphitcha Pongpak , Kulpiya Alisa , Poomthavorn Preamrudee

Background: Pediatric acute lymphoblastic leukemia survivors (pALL-S) carry a risk for developing metabolic abnormalities, including obesity, abnormal glucose metabolism (AGM) and dyslipidemia. Previous studies showed conflicting data regarding the pathophysiology of AGM in those survivors. Additionally, there has never been a study comparing glucose metabolism between pALL-S and simple obese children (Ob-C). This study aimed to assess glucose metabolism in pA...